Major Accomplishments of KIST Over Its 40-Year History. Since its foundation over 40 years ago, KIST has remained faithful to its role as a comprehensive research institute supporting Korea's interests and has made active contributions to the growth of the nation's industrial base through advancements in science and technology. A review of its major accomplishments through the years offer a peek into the most significant events in its history.

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Project Name Identification of Structure and Mechanism for Neurotransmitter Release Related with SNARE Protein
Year 2013 Director Dr. yeon-kyun shin
Attach

Identification of Structure and Mechanism for Neurotransmitter Release Related with SNARE Protein

 

1. Content & Characteristic

       O This research shows hidden structure and mechanism of SNARE proteins, which

          are thought to be the core machinery for neurotransmitter release, using

          magnetic tweezer in the single molecular level.

             - Development of new assay enables to observe the single protein transition at the force of

               piconewton and length of nanometer level.

            - Observation of the metastable intermediate in the SNARE complex and prediction of the

              structure of SNARE complex with precise measurement via developed assay.

            - Discovering that the partially assembled state has the effect of rectifying the direction of

              SNARE-complex formation, firmly pushing SNARE zippering towards the transmembrane

              domains.

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2. Scientific and Technological Value

       O Suggesting a clues to the mechanism-based design of new drugs for mental

          diseases, such as dementia, closely related to the neurotransmitter release

          process of SNARE proteins.

 

3. Social and Economic Effect

       O Development of infrastructure of neuronal communication research using

          ground-breaking new assay for neurotransmitter release.

       O Establishment of new concept of the pathochemical origin of dementia by the

          understanding of the molecular mechanism of neurotransmitter release.

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