The Center for Neuromedicine was founded with the goal of developing diagnostic tools and therapeutic agents for various diseases to promote quality of life. In particular, brain diseases such as ischemia, Parkinson's disease, Alzheimer's disease, epilepsy, depression, schizophrenia, and neuropathic pain are expected dramatically increase in an era of rapid population aging. Against this backdrop, our research is intensively focused on discovery and development of novel therapeutics for treatment of neurologic and psychiatric diseases. To accomplish these objectives, the Center has established a strong collaborative system in wide range of fields and maintains an excellent research environment including outstanding research scientists, professional expertise, and advanced instruments. The Center is currently expanding to explore novel drug targets for other intractable diseases in addition to the aforementioned brain diseases. New drug candidates are being thoroughly investigated with chemoinformatics tools based on KIST’s drug discovery system involving in-silico drug design, combinatorial chemistry, in vitro high throughput screening, and in vivo animal study.