Research Fields of KIST Professors

research fields list
Name Park Kwi Deok
Position(full time/adjunct) Full time Professor
KIST School Major Bio-Medical Science and Technology
Division / Center Biomedical Research Institute / Center for Biomaterials
Email kpark@kist.re.kr
Telephone +82-2-02-958-5288


Research Field & Research Interest
  • Biomedical Engineering, Biomedical Polymers, Tissue engineering, Stem cell bioengineering, Extracellular microenvironment, Growth factor delivery system


Research Project
  • Skin wound regeneration using ECM patch-based cells or drug delivery
  • Biomimetic cell stimulator using stretchable ECM membrane
  • Non-biodegradable hydrogels with fracture toughness (1000J/m2) and elastic modulus (5 MPa) for the replacement of intervertebral disc
  • Strategic investigation of domestic commercialization of biomedical materials
  • Fabrication of high strength hydrogel matrix and matrix-fiber-based hydrogel for articular cartilage replacement
  • Stem cell expansion using matrix plate and improvement of therapeutic efficacy of stem cells
  • Matrix-mediated large scale expansion of nasal chondrocyte with minimal cell dedifferentiation
  • Stem cell therapy for cartilage regeneration using cell-derived macromolecular matrix
  • In depth study of medical devices R&D for strategic investment
  • Engineered multi-scale environment for stem cell study
  • Study of bone regeneration using peptide hydrogel and multi-growth factor delivery microcapsule containing BMP-2 and VEGF
  • Construction of matrix-assisted composite for chondrogenesis of stem cells
  • Stem cell therapy for cartilage regeneration using cell-derived macromolecular matrix
  • Development of organic/inorganic hybrid scaffold for bone defect treatment
  • Development of bone defect treatment using both multi-growth factor delivery microcapsule and stem cell co-culture system
  • Development of Bio Absorbable Metal Plate and Screw for Bone Fixation
  • Hybrid coating on bioabsorbable metallic plate and screw
  • Treatment of bone defect using co-culture of adipose stem cells/bone marrow stromal cells and dual growth factor delivery system
  • Evaluation of porous polyvinylalcohol as a cartilage implant
  • Development of tissue-engineered bone using stem cell
  • Injectable scaffold for stem cell delivery with the improved cell binding and therapeutic potential
  • Study of Cell-Material Interface in 3-Dimensional Environment for Chondrocyte Redifferentiation


Paper Publication
Paper Publication
Title Author Journal Date Abstract
Therapeutic Ultrasound Effects on Interleukin-1?Stimulated Cartilage Construct in Vitro 박귀덕,B. Hoffmeister,한동근,K. Hasty, Ultrasound in medicine & biology 200702
Preparation of Biodegradable Polymer Scaffolds with Dual Pore System for Tissue Regeneration 박귀덕,정현정,손준식,박기동,김재진,안광덕,한동근, Macromolecular symposia 200703
Quantitative Analysis of Temporal and Spatial Variations of Chondrocyte Behavior in Engineered Cartilage during Long-Term Culture 박귀덕,민병현,한동근,K. Hasty, Annals of biomedical engineering 200703
Surface Modification of Biodegradable Electrospun Nanofiber Scaffolds and Their Interaction with Fibroblasts 박귀덕,주영민,손준식,안광덕,한동근, Journal of biomaterials science, Polymer edition 200704
Thermosensitive and Cell-Adhesive Pluronic Hydrogels for Human Adipose-Derived Stem Cells 박귀덕,정홍희,손준식,이종원,박기동,안광덕,한동근, Key engineering materials 200707
Functional PLGA Scaffold for Induction of Chondrogenesis of Mesenchymal Stem Cell 박귀덕,조경진,김익환,한동근, 세계생체재료학회 200805
Hydrophilization of Biodegradable Dual Pore Scaffolds and Its Effect on Osteoblast Adhesion 박귀덕,한동근, 대한창상학회지 = Journal of the Korean Wound Care Society 200811
Temporal Control of Dexamethasone Release and the Effect on In Vivo Chondrogenesis of Mesenchymal Stromal Cells (MSCs) 박귀덕,배순언,손준식,신흥수,한동근, Annual Meeting of Orthopaedic Research Society 200902
Dedifferentiated chondrocyte culture using alginate microbead prepared from microfluidic technique 박귀덕,황지영,김충,강지윤,전흥재,한동근, Tissue Engineering and Regenerative Medicine 200903
Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-derived Mesenchymal Stem Cell 박귀덕,조경진,김재진,김익환,한동근, Macromolecular bioscience 200903
Biomimetic PLGA-based composite scaffold for osteogenic 홍유진,한동근,김익환,박귀덕, 2009 춘계 한국고분자학회 200904
Efficacy of Pluronic/Hyaluronan Composite Hydrogel in Chondrogenesis of Human Adipose-Derived 박귀덕,정홍희,김재진,한동근, 2009 Annual Conference of Society For Biomaterials 200904
Induction of Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells Using Decellularized Scaffold 홍유진,김익환,한동근,박귀덕, 2nd Termis WC 국제학회 200909
Temporally Controlled Delivery of Dexamethasone and Its Effect on Chondrogenesis of Stem Cells 배순언,손준식,한동근,박귀덕, 2nd Termis WC 국제학회 200909
Biomedical Polymer Nanofibers for Emerging Technology 박귀덕,박원호,손준식,한동근, NanoScience in Biomedicine 200910
Osteogenic differentiation of rabbit bone marrow stromal cells in a biomimetic composite scaffold 홍유진,한동근,김익환,박귀덕, 2009 추계 한국고분자 학회 200910
PLGA microsphere/alginate system of dual growth factor delivery for stem cell differentiation 최동훈,박철호,한동근,김익환,박귀덕, 2009 추계 한국고분자 학회 200910
Decellularized porous scaffold for osteogenic differentiation of bone marrow-derived stromal cells 홍유진,한동근,김익환,박귀덕, 2009년 한국생체재료학회 200911
Fabrication of a dual growth factor delivery system using electro-dropping method 최동훈,한동근,김익환,박귀덕, 2009년 한국생체재료학회 200911
Decellularized surface modification for the osteogenic induction of Bone marrow-derived Mesenchymal Stromal Cells 홍유진,한동근,김익환,박귀덕, APMT 2010 201001
Dual growth factor delivery microcapsules and their effect on osteogenesis of rat BMSCs 최동훈,한동근,김익환,박귀덕, 2010년 한국생체재료학회 201003
Effect of Surface-activated PLLA Scaffold on Apatite Formation in Simulated Body Fluid 박귀덕,정현정,김재진,한동근, Journal of bioactive and compatible polymers 201003
Induction of osteogenesis of bone marrow-derived stromal cells using ECM-assembled scaffold 홍유진,한동근,김익환,박귀덕, 2010년 한국생체재료학회 201003
A dual growth factor delivery system of PLGA/alginate microcapsules using a coaxial system 최동훈,한동근,김익환,박귀덕, 2010년 춘계 고분자학회 201004
Acellularized Scaffold for Osteogenic Differentiation of Rabbit Bone Marrow Stromal Cells 홍유진,김익환,한동근,박귀덕, Society For Biomaterials 201004
Effect of temporally controlled release of dexamethasone on in vivo chondrogenic differentiation of mesenchymal stromal cells 배순언,최동훈,한동근,박귀덕, Journal of controlled release 201004
Dual growth factor delivery system for stem cell differentiation 최동훈,한동근,김익환,박귀덕, 2010년 12th 한국조직공학재생의학회 201006
Extracellular matrix (ECM)-assembled scaffold for osteogenic differentiation of bone marrow-derived stromal cells 홍유진,한동근,김익환,박귀덕, 2010년 12th 한국조직공학재생의학회 201006
Evaluation of osteogenic potential of extracellular matrices with preosteoblasts 배순언,한동근,박귀덕, MFMS2010/BIN Symposium 201009
Fabrication of core-shell microcapsules for a dual growth factor delivery 최동훈,한동근,박귀덕, MFMS2010/BIN symposium 201009
Induction of Chondrogenic or Osteogenic Differentiation Using Induced Pluripotent Stem (iPS) Cells for Tissue Engineering Applications 최동훈,유승권,김익환,한동근,박귀덕, Biomaterials Research 201009
Evaluation of different osteogenic potentials of naturally-derived extracellular matrices (ECM) in 2D configuration 배순언,한동근,박귀덕, 2010 한국고분자학회 추계학술대회 201010
Fabrication of Dual Growth Factor Delivery Microcapsules for Stem Cell Differentiation 최동훈,김익환,한동근,박귀덕, 대한정형외과연구학회 201010
Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system 최동훈,박철호,김익환,전흥재,박귀덕,한동근, Journal of controlled release 201010
Endothelial cells adhesion and growth on smooth muscle cell-derived ECM 이양기,한동근,신흥수,박귀덕, 2010년 한국생체재료학회 제18차 학술대회 201011
Induction of redifferentiation of dedifferentiated chondrocytes using naturally derived extracellular matrix 차명화,한동근,김익환,박귀덕, 2010년 한국생체재료학회 제18차 학술대회 201011
Multi-differentiation of hBMSC the naturally assembled ECM substrates 최동훈,한동근,김익환,박귀덕, 2010년 한국생체재료학회 제18차 학술대회 201011
Cell-derived Extracellular Matrix and Their Osteogenic Potential with Preosteoblasts 박귀덕,배순언,한동근, Orthopaedic Research Society 201101
Fabrication of temporary controlled growth factor delivery using a core-shell microcapsule 최동훈,한동근,김익환,박귀덕, Tissue Engineering and Regenerative Medicine(Korean Tissue Engineering and Regenerative Medicine Society)13th annual meeting 201105
Osteogenic differentiation of preosteoblasts on naturally derived extracellular microenvironment 박가람,한동근,이정완,박귀덕, Tissue Engineering and Regenerative Medicine(Korean Tissue Engineering and Regenerative Medicine Society)13th annual meeting 201105
DIFFERENTIATION OF HUMAN BONE MARROW STROMAL CELLS ON CELL-DERIVED MATRIX 최동훈,김익환,한동근,박귀덕, HISTOLOGY AND HISTOPATHOLOGY(termis EU 2011 Annual Meeting) 201106
Investigation of differentiation potential of naturally assembled 2D micro-environment using human bone marrow stromal cells 최동훈,한동근,김익환,박귀덕, 제 3회 아시아 생체재료학회 201109
Osteogenic differentiation of preosteoblasts on naturally obtained 2D biomimetic matrix 박가람,한동근,이재관,박귀덕, 제 3회 아시아 생체재료학회 201109
Decellularized PLGA-based scaffolds and their osteogenic potential with bone marrow stromal cells 홍유진,배순언,도선희,김익환,한동근,박귀덕, Macromolecular research 201110
Differentiation of human bone marrow stromal cells on naturally assembledextracellular matrix 최동훈,한동근,김익환,박귀덕, 2011년 추계학술대회 연구논문초록집 201110
Investigation of chondrogenic/ osteogenic differentiation of human bone marrow stromal cells using acellular 2D matrix microenvironment 최동훈,김익환,한동근,박귀덕, 대한정형외과 연구학회 201110
Study of chondrogenic/ osteogenic differentiation of human bone marrow stromal cells using acellular 2D matrix microenvironment 최동훈,한동근,김익환,박귀덕, 9th World Biomaterials Congress 201206
Characterization of Naturally Derived Macromolecular Matrix and Its Osteogenic Activity with Preosteoblasts 박가람,이재원,전흥재,한동근,박귀덕, Macromolecular research 201208
Self-assembled extracellular macromolecular matrices and their different osteogenic potential with preosteoblasts and rat bone marrow mesenchymal stromal cells 박귀덕,배순언,방석호,김병수, Biomacromolecules 201209
Study of endothelial cell behavior using cell-derived extracellular matrix environment 박귀덕,두 핑, 3rd TERMIS World Congress 201209
Effect of graphene-deposited titanium on osteogenic differentiation of preosteoblast 라메쉬,박귀덕, 한국생체재료학회 201211
Human umbilical vein endothelial cell (HUVEC) behavior on cell-derived macromolecular matrix environment 두 핑,박귀덕, 한국생체재료학회 201211
Induction of Re-Differentiation of Passaged Rat Chondrocytes Using a Naturally Obtained Extracellular Matrix Microenvironment 박귀덕,차명화,박가람,도선희,두 핑,한기철,한동근, Tissue engineering. Part A. 201304
Dual Growth factor Delivery using Biocompatible core-shell microcapsules for angiogenesis 최동훈,라메쉬,Ik Hwan Kim,한동근,박귀덕, Small 201310
Comparative study of passaged human umbilical cord-derived mesenchymal stem cells on different biophysical microenvironments 반세영,박귀덕, TERMIS-AP 201409
Human umbilical vein endothelial cells behavior on fibroblast-derived matrix via a physical or chemical modification 두 핑,라메쉬,수하에리,박귀덕, TERMIS-AP 201409
In situ delivery of BMP-2 and VEGF for osteogenesis of mesenchymal stem cells and bone regeneration in rat calvarial defect model 라메쉬,반세영,두 핑,노용권,김인걸,황민태,박귀덕, TERMIS-AP 201409
Induction of chondrogenesis using human fibroblast-derived matrix and placenta-derived mesenchymal stem cells 노용권,김인걸,두 핑,하철원,박귀덕, TERMIS-AP 201409
Multi-lineage differentiation of human mesenchymal stromal cells on the biophysical microenvironment of cell-derived matrix 최동훈,수하에리,황민태,김익환,한동근,박귀덕, Cell and tissue research 201409
Observation of cardiomyoblast differentiation on different ECM microenvironments 수하에리,반세영,라메쉬,두 핑,김인걸,박귀덕, TERMIS-AP 201409
Osteogenesis of human placenta-derived mesenchymal stem cell using biomimetic polymer mesh scaffold coated with BMP-2 tethered fibroblast derived matrix 김인걸,두 핑,고재훈,하철원,박귀덕, TERMIS-AP 201409
Vascular morphogenesis of human umbilical vein endothelial cells on cell-derived macromolecular matrix microenvironment 두 핑,라메쉬,박정환,박귀덕, Tissue engineering. Part A. 201409
Cell-derived Matrices as Biomimetic Substrates for Cardiomyobalst Differentiation 수하에리,황민태,김인걸,반세영,박귀덕, Biomedical Engineering Society (BMES) 201410
Fibroblast-derived matrix (FDM) as a novel vascular endothelial growth factor delivery platform 두 핑,황민태,노용권,라메쉬,김인걸,배순언,박귀덕, Journal of controlled release 201411
Fibronectin-tethered graphene oxide as an artificial matrix for osteogenesis 라메쉬,두 핑,반세영,수하에리,황민태,이강원,박귀덕, Biomedical materials 201412
Bioactive cell-derived matrices combined with polymer mesh scaffold for osteogenesis and bone healing 김인걸,황민태,두핑,고재훈,하철원,도선희,박귀덕, Biomaterials 201505
Cardiomyoblast (H9c2) Differentiation on Tunable Extracellular Matrix Microenvironment 수하에리,라메쉬,반세영,두핑,김인걸,이강원,박귀덕, Tissue engineering. Part A. 201506
Osteogenic/Angiogenic Dual Growth Factor Delivery Microcapsules for Regeneration of Vascularized Bone Tissue 라메쉬,황민태,반세영,도선희,박한수,이강원,김상헌,윤규식,박귀덕, Advanced Healthcare Materials 201509
Investigation of the changes of biophysical/ mechanical characteristics of differentiating preosteoblasts in vitro 라메쉬,수하에리,황민태,김우준,박귀덕, Biomaterials Research = 생체재료학회지 201512
Elasticity Modulation of Fibroblast-Derived Matrix for Endothelial Cell Vascular Morphogenesis and Mesenchymal Stem Cell Differentiation 두핑,수하에리,Ramesh Subbiah,반세영,박지민,김상헌,박귀덕,이강원, Tissue engineering. Part A. 201603
Mesenchymal cells condensation-inducible mesh scaffolds for cartilage tissue engineering 김인걸,고재훈,이혜림,도선희,박귀덕, Biomaterials 201604
Polymer mesh scaffold combined with cell-derived ECM for osteogenesis of human mesenchymal stem cells 노용권,Ping Du,김인걸,고재훈,김성후,박귀덕, Biomaterials Research 201604
Approximating bone ECM: Crosslinking directs individual and coupled osteoblast/osteoclast behavior Mintai P. Hwang,Ramesh Subbiah,김인걸,이경은,박지민,김상헌,박귀덕, Biomaterials 201610
Tunable Crosslinked Cell-Derived Extracellular Matrix Guides Cell Fate Ramesh Subbiah,Mintai P. Hwang,Ping Du,수하에리,황준하,홍정호,박귀덕, Macromolecular bioscience 201611
Novel platform of cardiomyocyte culture and coculture via fibroblast-derived matrix-coupled aligned electrospun nanofiber 김수현,김종현,오승자,김상헌,박귀덕,Muhammad Suhaeri,Ramesh Subbiah, ACS Applied Materials & Interfaces 201701
Human lung fibroblast-derived matrix facilitates vascular morphogenesis in 3D environment and enhances skin wound healing 두핑,수하에리,하상수,오승자,김상헌,박귀덕, Acta Biomaterialia 201704
Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix 김인걸,길창현,Joseph Seo,Soon-Jung Park,Ramesh Subbiah,Taek-Hee Jung,Jong Soo Kim,Young-Hoon Jeong,Hyung-Min Chung,이종호,Man Ryul Lee,Sung-Hwan Moon,박귀덕, Biomaterials 201801


Patent
Patent
Subject Registration No. Date Country
Pharmaceutical composition for wound healing or tissue regeneration, preparation method thereof, and use thereof 20171123 Republic of Korea
A Cross-linked extracellular matrix and a Culturing method of human pluripotent stem cell using thereof 20170825 Republic of Korea
Composite of silk fiber and poly(vinyl alcohol), preparation method thereof, and use thereof 20170526 Republic of Korea
Microfiber scaffold coated with bone morphogenetic protein (BMP)-2 tethered cell-derived matrix and use there of 10-1737548 20170512 Republic of Korea
Method of three-dimensional vessel model preparation and its applications 20170421 Republic of Korea
Method of producing cross-linked PVA-ECM composite and PVA-ECM composite thereby 10-1714695 20170303 Republic of Korea
Development of Contrast Agents for Topical Use for The Selective Labeling for Cancerous Lesions using A Hydrogel-based Nano-emulsions 20170224 PCT
Heparin and growth factor-immobilized cell-derived matrices and their applications for therapeutic purpose 10-1703917 20170201 Republic of Korea
Method of producing cross-linked PVA-ECM composite and PVA-ECM composite thereby 20160715 PCT
Development of Contrast Agents for Topical Use for The Selective Labeling for Cancerous Lesions using A Hydrogel-based Nano-emulsions 20160629 Republic of Korea
Method of producing cross-linked PVA-ECM composite and PVA-ECM composite thereby 20160516 United States of America
Method of the preparation of cell-derived biomimetic nanostructural matrix and their applications for the proliferation and dif 10-1528909 20150608 Republic of Korea
Method of the preparation of cell-derived biomimetic nanostructural matrix and their applications for the proliferation and dif 20141010 Republic of Korea
Method of the fabrication of a dual growth factor delivery system for stem cell differentiation 10-1270161 20130527 Republic of Korea
Method of the preparation of cell-derived biomimetic nanostructural matrix and their applications for the proliferation and dif 20121012 United States of America
Method of the preparation of cell-derived biomimetic nanostructural matrix and their applications for the proliferation and dif 20111014 Republic of Korea
Method of the fabrication of a dual growth factor delivery system for stem cell differentiation 20101012 United States of America
Surface modification of polymer scaffold for stem cells using decellularized extracellular matrix 20091020 Republic of Korea
Surface modification of polymer scaffold for stem cells using decellularized extracellular matrix 20090416 United States of America