Research Fields of KIST Professors

research fields list
Name Sehoon Kim
Position(full time/adjunct) Full time Professor
KIST School Major Bio-Medical Science and Technology
Division / Center Biomedical Research Institute / Center for Theragnosis
Email sehoonkim@kist.re.kr
Telephone +82-2-02-958-5924


Research Field & Research Interest
  • Biomedical Engineering, Biomedical Polymer,nanomedicine, biophotonic nanomaterials, drug delivery system, organic-polymeric metarials chemistry, molecular imaging


Research Project
  • Support in imaging probe and molecular imaging technology for preclinical trials of new drugs
  • Development of Electrochemiluminescent Redox Nanosensors for Multiple Reactive Chemical Species and Analysis of Disease-Specific Sensing Patterns
  • Sustainable Physioflame: Self-Powered Long-Lasting Physioluminescence
  • Development of low-cost/high-performance bio-detection platform based on surface-initiated chromogenesis reaction amplification and linear up-converted fluorescence
  • Development of non-toxic organic nanoparticles for establishing next-generation cutting-edge medical metrology platform
  • Development of excipient repositioning-based cancer imaging agents to reduce social cost of cancer treatment
  • Molecular Imaging and Nanomedicine for Theragnosis using Nano-bio Materials
  • Development of low-cost/high-performance bio-detection technology based on surface-initiated chromogenesis reaction amplification and linear up-converted fluorescence
  • Development of multi-target imaging fluorescent probes for diagnosis and mechanistic study of lymph node metastasis
  • Development of fluorescent contrast agents for improving precision of local disease visualization and image-guided dissection
  • Development of highly fluorinated theragnostic nanoswitches
  • The development of photosensitizer nanocarrier system for targeted photodynamic therapy of breast cancer
  • Development of biological-stimuli responsible polymer-biomolecule hybrid innovative materials
  • Development and Biophotonics Application of Multi-Molecule Integrated Emissive Nanoparticles
  • Development of nonFRET-based universal/multidimensional quencher labels for the preparation of high-performance fluorescence imaging/diagnosis probes
  • Development of nano-bio materials and systems for the detection and imaging of oxygen species


Paper Publication
Paper Publication
Title Author Journal Date Abstract
Aggregation-Enhanced Two-Photon Fluorescence for Nanobiophotonics 김세훈, 한국고분자학회 춘계 연구논문 발표회 200804
Dye-Encapsulating Organically Modified Silica Nanoparticles for Nanobiophotonics 김세훈, 한국공업화학회 춘계 연구논문 발표회 200805
Biocompatible and AIEE Active Red Nanoparticles for Bioimaging 임창근,김세훈,김광명,권익찬,안철희,박수영, The 7th KCIST International Conference 200808
Efficient in vivo tumor imaging with fluorophore by enhanced quantum efficiency according to increase of substituent molecular weight 이용덕,김세훈, 대한화학회 학술발표회 200904
Synthesis and nanoparticle encapsulation of 3,5-difuranylvinyl-boradiaza-s-indacenes for near-infrared fluorescence imaging 김세훈,Tymish Y. Ohulchansk,Alexander Baev,Paras N. Prasad, Journal of materials chemistry 200905
Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy 김세훈,Tymish Ohulchanskyy,Dhruba Bharali,Yihui Chen,Ravindra Pandey,Paras N. Prasad, The journal of physical chemistry. C, Nanomaterials and Interfaces. 200906
Aggregation enhanced near-infrared fluorophore for in vivo imaging 이용덕,임창근,김세훈, KJF International conference on organic materials for electronics and photonics 200908
Fluorescent Organic Dots for Biological Labeling 엄민영,임창근,고준석,김세훈, KJF International conference on organic materials for electronics and photonics 200908
NIR Chemiluminescent Organic Nanoparticle for In Vivo/Vitro Hydrogen Peroxide Imaging 임창근,나진희,이용덕,김세훈, KJF International conference on organic materials for electronics and photonics 200908
Semiconducting Organic Polymer Dots for Sentinel Lymph Node Mapping by Fluorescence Imaging 김세훈,김광명,최귀원,James F. Leary,권익찬, World Molecular Imaging Congress 200909
Dye-Condensed Biopolymeric Hybrids: Chromophoric Aggregation and Self-Assembly toward Fluorescent Bionanoparticles for Near Infrared Bioimaging 임창근,김세훈,권익찬,안철희,박수영, Chemistry of materials 200912
Densely Integrated Polymer Nanoparticles for Biophotonics Applications 김세훈, 한국광학회 201001
Conjugated polymer nanoparticles for biomedical in vivo imaging 김세훈,임창근,나진희,이용덕,김광명,최귀원,James F. Leary,권익찬, Chemical communications 201003
Dye-Condensed Polymeric Hybrids: Chromophoric Self-Assembly toward Fluorescently Glowing Nanoparticles for Bioimaging 임창근,이용덕,김세훈,권익찬,안철희,박수영, 239th ACS National Meeting, San Francisco, CA 201003
Fabrication of Nanohydrogels via Hydrogen Bonding-mediated Physical Gelation of Synthetic Hydroxyl-rich Polyamides 정근수,김세훈,박종래, 대한화학회 제105회 2010년 춘계 201004
Synthesis of hydroxyl-rich polyamides and their hydrogen bonding-mediated physical hydrogelation 정근수,임창근,김세훈,박종래, 한국고분자학회 201004
Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo 임창근,이용덕,나진희,오정민,허송욱,김광명,최귀원,김세훈,권익찬, Advanced functional materials 201008
Conjugated Polymer/Photochromic Dye Integrated Binary Nanoparticles: Stable and Reversible Fluorescence Photoswitching for Bioimaging 정근수,이용덕,임창근,김세훈,박종래, KJF International Conference on Organic Materials for Electronics and Photonics 201008
Conjugated Polymer/Photochromic Dye Intergrated Binary Nanoparticles: Stable and Reversible Fluorescence Photoswitching for Bioimaging 정근수,이용덕,임창근,김세훈,박종래, KIST-Tohoku Joint Symposium on Nanobiomedical Engineering 201008
Dye-Condensed Polymeric Hybrids: Chromophoric -Assembly Toward Fluorescent Nanoparticles for Bioimaging 임창근,이용덕,김세훈,권익찬, KIST-Tohoku Joint Symposium on Nanobiomedical Engineering 201008
Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Cellular Imaging 이용덕,임창근,김세훈,권익찬, KIST-Tohoku Joint Symposium on Nanobiomedical Engineering 201008
Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Cellular and In Vivo Imaging 이용덕,임창근,김세훈,권익찬,김정안, KJF International Conference on Organic Materials for Electronics and Photonics 201008
Nanointegrated Molecular Fluorescence for Advanced Bioimaging 김세훈, Bio Korea 2010 Conference & Exhibition 201009
Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Bioimaging 이용덕,임창근,김세훈,권익찬,김정안, Advanced functional materials 201009
Densely Integrated Organic Nanomaterials for Biophotonics 김세훈, 한국생체역학회 201012
Heavy-Atomic Construction of Photosensitizer Nanoparticles for Enhanced Photodynamic Therapy of Cancer 임창근,신지영,이용덕,김정안,박호용,권익찬,김세훈, Small 201101
Concentration and pH-modulated dual fluorescence in self-assembled nanoparticles of phototautomerizable biopolymeric amphiphile 임창근,서장원,김세훈,권익찬,안철희,박수영, Dyes and pigments 201109
Multi-Molecule Integration into Biophotonic Nanoparticles with Enhanced Luminescence 김세훈, 대한화학회 201109
Optical Molecular Imaging Probes 김세훈, 분자영상학회 201111
Iodinated Photosensitizing Chitosan: Self-Assembly into Tumor-Homing Nanoparticles with Enhanced Singlet Oxygen Generation 임창근,신지영,권익찬,정서영,김세훈, Bioconjugate chemistry 201205
Multi-molecule integrated nanoparticles for biophotonics 김세훈, 일본고분자학회 201205
Nanointegration-Induced Photophysics Modification for Advanced Photodynamic Therapy 김세훈, Seventh International Conference on Porphyrins and Phthalocyanines (ICPP-7) 201207
Self-Deprotonation and Colorization of 1,3-Bis(dicyanomethylidene)indan in Polar Media: A Facile Route to a Minimal Polymethine Dye for NIR Fluorescence Imaging 허정윤,임창근,황동렬,신지영,정서영,박수영,권익찬,김세훈, Chemistry : a European journal 201207
Dye/Peroxalate Aggregated Nanoparticles with Enhanced and Tunable Chemiluminescence for Biomedical Imaging of Hydrogen Peroxide 이용덕,임창근,아제이싱,고준석,김정안,권익찬,김세훈, ACS Nano 201208
Phthalocyanine-aggregated polymeric nanoparticles as tumor-homing near-infrared absorbers for photothermal therapy of cancer Chang-Keun Lim,Jiyoung Shin,이용덕,Jungahn Kim,Keun Sang Oh,Soon Hong Yuk,Seo Young Jeong,권익찬,김세훈, Theranostics 201209
Tuning Solid-State Fluorescence to the Near-Infrared: A Combinatorial Approach to Discovering Molecular Nanoprobes for Biomedical Imaging 아제이싱,임창근,이용덕,맹준호,이상엽,고준석,김세훈, ACS Applied Materials & Interfaces 201306
Nanophotosensitizers toward advanced photodynamic therapy of Cancer 임창근,허정윤,신승훈,정근수,서영훈,장우동,박종래,박수영,김세훈,권익찬, Cancer letters 201307
Poly(oxyethylene sugaramide)s: unprecedented multihydroxyl building blocks for tumor-homing nanoassembly 정근수,이용덕,박솔지,이은정,임창근,이경은,전혜성,김정안,권익찬,박종래,김세훈, Journal of materials chemistry. B, Materials for biology and medicine 201307
Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron 김경란,이용덕,이태민,김병수,김세훈,안대로, Biomaterials 201307
Water-Soluble Fluorinated and PEGylated Cyanostilbene Derivative: An Amphiphilic Building Block Forming Self-Assembled Organic Nanorods with Enhanced Fluorescence Emission 신승훈,Ghim, Se Hoon,박종래,김세훈,박수영, Chemistry of materials 201307
Multimolecule-Integrated Biophotonic Nanoparticles for Disease Imaging 김세훈, German-Korean Polymer Symposium 201308
Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging 임창근,아제이싱,허정윤,김대홍,이경은,전혜성,고준석,권익찬,김세훈, Biomaterials 201309
Conjugated Polymer/Photochromophore Binary Nanococktails: Bistable Photoswitching of Near-Infrared Fluorescence for In Vivo Imaging 정근수,박솔지,이용덕,임창근,김정안,정봉현,권익찬,박종래,김세훈, Advanced materials 201310
Prognostic Significance of Epithelial-Mesenchymal Transition of Extracapsular Spread Tumors in Lymph Node Metastases of Head and Neck Cancer 이원용,신다용,김혜진,고영혜,김세훈,정한신, Annals of surgical oncology 201406
Natural Oil-Based Chemiluminescent Nanodroplets for In vivo Imaging of Hydrogen Peroxide Ajay Singh,조홍준,이상엽,고준석,김세훈, Macromolecular research 201410
Amphiphilized poly(ethyleneimine) nanoparticles: a versatile multi-cargo carrier with enhanced tumor-homing efficiency and biocompatibility 박솔지,정근수,이은정,이재혁,이지영,아제이싱,고준석,이상엽,김광명,권익찬,박종래,김정안,김세훈, Journal of materials chemistry. B, Materials for biology and medicine 201501
Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging 서영훈,조민주,정욱재,장우동,Tymish Y. Ohulchanskyy,이상엽,최동훈,Paras N. Prasad,김세훈, Biomaterials 201501
Prolonged chemiluminescence of CuInS2-based nanocrystals 김영선,김세훈, 2015 MRS spring meeting 201504
Organelle specific imaging in live cells and immuno-labeling using resonance Raman probe Yuee Li,허정윤,임창근,Artem Pliss,Aliaksandr V. Kachynski,Andrey N. Kuzmin,김세훈,Paras N. Prasad, Biomaterials 201506
Co-delivery of chemosensitizing siRNA and an anticancer agent via multiple monocomplexation-induced hydrophobic association 이은정,오창화,김인산,권익찬,김세훈, Journal of controlled release 201507
Directed molecular assembly into a biocompatible photosensitizing nanocomplex for locoregional photodynamic therapy 이용덕,이상엽,권익찬,김세훈,조홍준,최미화,Park, Hoyong,Bang, Joona, Journal of controlled release 201507
Biolighted Nanotorch Capable of Systemic Self-Delivery and Diagnostic Imaging 서영훈,권익찬,김세훈,Ajay Singh,Chang-Keun Lim,Joonseok Koh,Woo-Dong Jang, ACS Nano 201509
Fluorogenic nanoreactor assembly with boosted sensing kinetics for timely imaging of cellular hydrogen peroxide 허정윤,임창근,김영선,조홍준,이용덕,맹준호,안대로,이상엽,방준하,박수영,김세훈, Chemical communications 201601
Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy 정근수,강지수,김영선,이용덕,권익찬,김세훈, Cancer letters 201604
Nanoprobes for optical bioimaging 정근수,김영선,강지수,조홍준,이용덕,권익찬,김세훈, Optical Materials Express 201604
Preparation of Fluorous Solvent-Dispersed Fe3O4 Nanocrystals: Role of Oxygen in Ligand Exchange 김영선,이상엽,김세훈, Langmuir 201604
Rational design for enhancing inflammation-responsive in vivo chemiluminescence via nanophotonic energy relay to near-infrared AIE-active conjugated polymer 서영훈,Ajay Singh,조홍준,김영선,허정윤,임창근,박수영,장우동,김세훈, Biomaterials 201604
Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species 허정윤,임창근,Alexander Baev,Andrey N. Kuzmin,박수영,Paras N. Prasad,김세훈, Dyes and pigments 201607
Size-engineered biocompatible polymeric nanophotosensitizer for locoregional photodynamic therapy of cancer 정근수,박솔지,이용덕,강지수,김현준,박현종,권익찬,김정안,박종래,김세훈, Colloids and surfaces. B, Biointerfaces 201608
Activatable iRGD-based peptide monolith: Targeting, internalization, and fluorescence activation for precise tumor imaging 조홍준,이성진,Chang H. Paik,이상명,김세훈,이윤식,Park, Sung-Jun, Journal of controlled release 201609
Multifunctional Photonics Nanoparticles for Crossing the Blood-Brain Barrier and Effecting Optically Trackable Brain Theranostics Ajay Singh,Woong Kim,김영선,정근수,강지수,김영수,고준석,Supriya D. Mahajan,Paras N. Prasad,김세훈, Advanced functional materials 201609
Pyrrolic molecular rotors acting as viscosity sensors with high fluorescence contrast 이승철,허정윤,류종완,이창렬,김세훈,태준성,이병옥,김상욱,권오필, Chemical communications 201612
A fluorogenic molecular nanoprobe with an engineered internal environment for sensitive and selective detection of biological hydrogen sulfide 김명,서영훈,김영선,허정윤,장우동,심상준,김세훈, Chemical communications 201702
How Can Doxorubicin Loading Orchestrate in Vitro Degradation Behaviors of Mesoporous Silica Nanoparticles under a Physiological Condition? 최은실,김세훈, Langmuir 201705
An activatable anticancer polymer-drug conjugate based on the self-immolative azobenzene motif 엄태웅,유원재,이용덕,박재형,최영손,방준하,김세훈,Anzar Khan, Journal of materials chemistry. B, Materials for biology and medicine 201706
Chemiluminescence Imaging of Duox2-Derived Hydrogen Peroxide for Longitudinal Visualization of Biological Response to Viral Infection in Nasal Mucosa 김현직,서영훈,안수진,권익찬,조아라,김세훈, Theranostics 201802
Molecular Viscosity Sensors with Two Rotators for Optimizing the Fluorescence Intensity-Contrast Trade-off Seung-Chul Lee,Chang-Lyoul Lee,허정윤,Chan-Uk Jeong,Gyeong-Hui Lee,김세훈,Woojin Yoon,Hoseop Yun,Sung O. Park,Sang Kyu Kwak,Sung-Ha Park,O-Pil Kwon, Chemistry : a European journal 201802
Near-infrared fluorescent probes for detection of glutathione and their applications in fluorescent imaging in living cells and tumor-bearing mouse 이다영,정근수,Xiao Luo,김가영,양유준,Xiaoqiang Chen,김세훈,윤주영, Journal of materials chemistry. B, Materials for biology and medicine 201805
Nootropic nanocomplex with enhanced blood-brain barrier permeability for treatment of traumatic brain injury-associated neurodegeneration 박정민,최은실,신슬기,임성수,김도희,백수지,이강파,이재준,이병한,김보경,정근수,백자현,김윤경,김세훈, Journal of controlled release 201808
Fluorescent Molecular Rotors for Viscosity Sensors 이승철,허정윤,우희철,이지안,서영훈,이창렬,김세훈,권오필, Chemistry : a European journal 201809
Simultaneous Delivery of Electrostatically Complexed Multiple Gene-Targeting siRNAs and an Anticancer Drug for Synergistically Enhanced Treatment of Prostate Cancer 최은실,유원재,박재형,김세훈, Molecular pharmaceutics 201809
Biologically activatable azobenzene polymers targeted at drug delivery and imaging applications 엄태웅,유원재,김세훈,Anzar Khan, Biomaterials 201812
Surface pH buffering to promote degradation of mesoporous silica nanoparticles under a physiological condition 최은실,김세훈, Journal of colloid and interface science 201901


Patent
Patent
Subject Registration No. Date Country
Hybrid Nanoprobes Photoinflatable in situ to Microsize for Dual Modality, Ultrasound and Photoluminescence, Imaging and Ultrasound-triggered Release United States of America
Nanocomplexs for Co-delivering a Drug and siRNA and Uses Thereof United States of America
DETECTION METHOD OF BIOMOLECULE USING LINEAR UPCONVERSION FLUORESCENT People's Republic of China
암 림프절 전이의 조기 진단 및 기전 탐색을 위한 펩타이드 기반의 이중-형광 고분자 나노프로브 제조 및 이의 용도 10-1896145 20180831 Republic of Korea
An siRNA delivery system comprising mesoporous silica particle and metal ions, to which siRNAs enable to bind, on the surface and within the pores of the particle, a preparation method thereof and use thereof 20180809 Republic of Korea
Reactive fluorogenic compound and nanocomposite for sensing hydrogen sulfide comprising the same 20180713 United States of America
Nanoparticles comprising near infrared absorption dye, a method for producing thereof, and use thereof 20180711 Republic of Korea
Magnetic nanoparticles with enhanced dispersion property in a fluorous solvent and a preparation method thereof 10-1852066 20180419 Republic of Korea
A siRNA delivery system in which siRNA and mesoporous silica nanoparticle are glued by metal ion, a preparation method thereof and use thereof 20180319 Republic of Korea
DETECTION METHOD OF BIOMOLECULE USING LINEAR UPCONVERSION FLUORESCENT 20180316 United States of America
Oxamide nanogel, a preparation method of the same and use thereof 10-1823490 20180124 Republic of Korea
Multifunctional polymeric nanoparticle for diagnosis or treatment of cerebral diseases and a preparation method thereof 10-1811384 20171215 Republic of Korea
Nanoparticles comprising emissive polymers and preparation method thereof 602009049691.3 20171206 Germany
Nanoparticles comprising emissive polymers and preparation method thereof 2251043 20171206 French Republic
Nanoparticles comprising emissive polymers and preparation method thereof 2251043 20171206
Nanoparticles comprising emissive polymers and preparation method thereof 2251043 20171206 United Kingdom of Great Britain
Reactive fluorogenic compound and nanocomposite for sensing hydrogen sulfide comprising the same 20170908 Republic of Korea
Oxamide nanogel, a preparation method of the same and use thereof 20170428 United States of America
Magnetic nanoparticles with enhanced dispersion property in a fluorous solvent and a preparation method thereof 20170327 PCT
Biocompatible Fluorescence Nanoparticles and Uses Thereof 10-1718867 20170316 Republic of Korea
Multifunctional polymeric nanoparticle for diagnosis or treatment of cerebral diseases and a preparation method thereof 20161128 United States of America
Methylene Blue Nanoparticle for Bioimaging and Photodynamic Therapy and Use Thereof 10-1673260 20161101 Republic of Korea
DETECTION METHOD OF BIOMOLECULE USING LINEAR UPCONVERSION FLUORESCENT 20160516 Republic of Korea
DETECTION METHOD OF BIOMOLECULE USING LINEAR UPCONVERSION FLUORESCENT 20160516 PCT
Medical Device Set for Optical Fiber Laser Ablation and Photodynamic Therapy, and Cancer Treatment Therapy Using the Same 10-1610203 20160401 Republic of Korea
DETECTION METHOD OF BIOMOLECULE USING LINEAR UPCONVERSION FLUORESCENT 20150515 Republic of Korea
SULFONATED BENZENE COMPOUNDS AND FLUORESCENT NANOPROBE COMPOSED OF THE SAME AND ORGANIC BASE 9012230 20150421 United States of America
Methylene Blue Nanoparticle for Bioimaging and Photodynamic Therapy and Use Thereof 20150325 United States of America
Nanocomplexs for Co-delivering a Drug and siRNA and Uses Thereof 20150121 Republic of Korea
Gd-PEI Nanogel and Contrast Agent or Pharmaceutical Composition Comprising the Same 1454236 20141017 Republic of Korea
단당류/에틸렌 옥사이드 교대 폴리아미드의 자기 조립 나노 입자 및 이의 제조 방법과 용도 1396880 20140513 Republic of Korea
Methylene Blue Nanoparticle for Bioimaging and Photodynamic Therapy and Use Thereof 20140326 Republic of Korea
SULFONATED BENZENE COMPOUNDS AND FLUORESCENT NANOPROBE COMPOSED OF THE SAME AND ORGANIC BASE 1311224 20130912 Republic of Korea
AQUEOUS DISPERSION OF ORGANIC NANO-PHOTOSENSITIZER CONTAINING HEAVY-ATOMIC DISPERSING AGENT, AND PREPARATION METHOD AND USE THE 10-1286059 20130709 Republic of Korea
Nanoparticles comprising emissive polymers and preparation method thereof 8,367,042 20130205 United States of America
AQUEOUS DISPERSION OF NEAR-INFRARED PHOTOTHERMAL ORGANIC NANOPARTICLES, AND PREPARATION METHOD AND USE THEREOF 1213409 20121212 Republic of Korea
Nanoparticles comprising emissive polymers and preparation method thereof ZL200910180478.6 20120926 People's Republic of China
Compositions and manufacturing method of chemiluminescent nanoparticles for in vivo/in vitro detection of hydrogen peroxide 10-1081409 20111102 Republic of Korea
Nanoparticles comprising emissive polymers and preparation method thereof 1065241 20110908 Republic of Korea